Učitavanje...
Mutations Y493G and K546D in human HSP90 disrupt binding of celastrol and reduce interaction with Cdc37
Celastrol, a natural compound derived from the Chinese herb Tripterygium wilfordii Hook F, has been proven to inhibit heat shock protein 90 (HSP90) activity and has attracted much attention because of its promising effects in cancer treatment and in ameliorating degenerative neuron diseases. However...
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| Izdano u: | FEBS Open Bio |
|---|---|
| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4932452/ https://ncbi.nlm.nih.gov/pubmed/27398312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12081 |
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