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The double edge of the HSP90–CDC37 chaperone machinery: opposing determinants of kinase stability and activity

The molecular chaperone HSP90, in concert with the co-chaperone CDC37, facilitates the maturation and modulates the activity of a variety of protein kinases. In this article, Gaude and colleagues described the dual activities of the HSP90–CDC37 chaperone machinery in maintaining the stability while...

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Autores principales: Xu, Wanping, Neckers, Len
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458789/
https://ncbi.nlm.nih.gov/pubmed/22894668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.12.80
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