Molecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy

Por Neckers, Len, Tatu, Utpal
Publicado em 2008

Just say NO: nitric oxide regulation of Hsp90

Por Scroggins, Bradley T., Neckers, Len
Publicado em 2009

A network of its own: The unique interactome of the HSP90 co-chaperone, Sba1/p23

Por Prince, Thomas, Neckers, Len
Publicado em 2011

Post-translational modifications of Hsp90 and their contributions to chaperone regulation

Por Mollapour, Mehdi, Neckers, Len
Publicado em 2011

Hsp90 molecular chaperone inhibitors: Are we there yet?

Por Neckers, Len, Workman, Paul
Publicado em 2012

The double edge of the HSP90–CDC37 chaperone machinery: opposing determinants of kinase stability and activity

Por Xu, Wanping, Neckers, Len
Publicado em 2012

Clients Place Unique Functional Constraints on Hsp90

Por Zuehlke, Abbey D., Neckers, Len
Publicado no Trends Biochem Sci (2016)

Impact of heat-shock protein 90 on cancer metastasis

Por Tsutsumi, Shinji, Beebe, Kristin, Neckers, Len
Publicado em 2009

Ras, ROS and proteotoxic stress: A delicate balance

Por Xu, Wanping, Trepel, Jane, Neckers, Len
Publicado em 2011

New Insights into von Hippel-Lindau Function Highlighted by Investigation of the Trichloroethylene-Induced p.P81S Hotspot Mutation

Por Neckers, Len, Ricketts, Christopher J., Marston Linehan, W.
Publicado em 2013

Regulation and function of the human HSP90AA1 gene

Por Zuehlke, Abbey D., Beebe, Kristin, Neckers, Len, Prince, Thomas
Publicado no Gene (2015)

Loss of Hsp90 Association Up-Regulates Src-Dependent ErbB2 Activity

Por Xu, Wanping, Yuan, Xitong, Beebe, Kristin, Xiang, Zhexin, Neckers, Len
Publicado em 2007

Targeting Hsp90 prevents escape of breast cancer cells from tyrosine kinase inhibition

Por Pashtan, Itai, Tsutsumi, Shinji, Wang, Suiquan, Xu, Wanping, Neckers, Len
Publicado em 2008

Coordinated Regulation of Serum- and Glucocorticoid-inducible Kinase 3 by a C-terminal Hydrophobic Motif and Hsp90-Cdc37 Chaperone Complex

Por Wang, Yuanzhong, Xu, Wanping, Zhou, Dujin, Neckers, Len, Chen, Shiuan
Publicado em 2014

Casein kinase 2 phosphorylation of Hsp90 threonine 22 modulates chaperone function and drug sensitivity

Por Mollapour, Mehdi, Tsutsumi, Shinji, Kim, Yeong Sang, Trepel, Jane, Neckers, Len
Publicado em 2011

Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Por Xu, Wanping, Marcu, Monica, Yuan, Xitong, Mimnaugh, Edward, Patterson, Cam, Neckers, Len
Publicado em 2002

KIT regulates tyrosine phosphorylation and nuclear localization of β-catenin in mast cell leukemia

Por Kajiguchi, Tomohiro, Lee, Sunmin, Lee, Min-Jung, Trepel, Jane B., Neckers, Len
Publicado em 2007

Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1α

Por Marcu, Monica G., Doyle, Melissa, Bertolotti, Anne, Ron, David, Hendershot, Linda, Neckers, Len
Publicado em 2002

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.

Por Jung, YunJin, Isaacs, Jennifer S, Lee, Sunmin, Trepel, Jane, Liu, Zheng-Gang, Neckers, Len
Publicado em 2003

Tumour necrosis factor receptor 1 mediates endoplasmic reticulum stress-induced activation of the MAP kinase JNK

Por Yang, Qingfeng, Kim, You-Sun, Lin, Yong, Lewis, Joseph, Neckers, Len, Liu, Zheng-Gang
Publicado em 2006