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KIT regulates tyrosine phosphorylation and nuclear localization of β-catenin in mast cell leukemia

Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of...

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Bibliographische Detailangaben
Hauptverfasser: Kajiguchi, Tomohiro, Lee, Sunmin, Lee, Min-Jung, Trepel, Jane B., Neckers, Len
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682210/
https://ncbi.nlm.nih.gov/pubmed/17949810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2007.08.023
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