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KIT regulates tyrosine phosphorylation and nuclear localization of β-catenin in mast cell leukemia
Gain-of-function mutations in the proto-oncogene c-kit that induce constitutive kinase activity of its product, KIT protein, are characteristic of human mast cell disease and are believed to play a central role in mast cell leukemia oncogenesis, proliferation and survival. Nuclear overexpression of...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2682210/ https://ncbi.nlm.nih.gov/pubmed/17949810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.leukres.2007.08.023 |
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