Tracing Nutrient Flux Following Monocarboxylate Transporter-1 Inhibition with AZD3965

The monocarboxylate transporter 1 (MCT1) is a key element in tumor cell metabolism and inhibition of MCT1 with AZD3965 is undergoing clinical trials. We aimed to investigate nutrient fluxes associated with MCT1 inhibition by AZD3965 to identify possible biomarkers of drug action. We synthesized an (...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Braga, Marta, Kaliszczak, Maciej, Carroll, Laurence, Schug, Zachary T., Heinzmann, Kathrin, Baxan, Nicoleta, Benito, Adrian, Valbuena, Gabriel N., Stribbling, Stephen, Beckley, Alice, Mackay, Gillian, Mauri, Francesco, Latigo, John, Barnes, Chris, Keun, Hector, Gottlieb, Eyal, Aboagye, Eric O.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7352845/
https://ncbi.nlm.nih.gov/pubmed/32604836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12061703
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