Genomic modeling of tumor onset and progression in a mouse model of aggressive human liver cancer

Por Coulouarn, Cédric, Factor, Valentina M., Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2011

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair

Por Huh, Chang-Goo, Factor, Valentina M., Sánchez, Aránzazu, Uchida, Koichi, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2004

E2F1 Inhibits c-Myc-driven Apoptosis via PIK3CA/Akt/mTOR and COX-2 in a Mouse Model of Human Liver Cancer

Por Ladu, Sara, Calvisi, Diego F., Conner, Elizabeth A., Farina, Miriam, Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2008

Hepatocyte-specific c-Met Deletion Disrupts Redox Homeostasis and Sensitizes to Fas-mediated Apoptosis

Por Gómez-Quiroz, Luis E., Factor, Valentina M., Kaposi-Novak, Pal, Coulouarn, Cedric, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2008

Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer

Por Calvisi, Diego F., Ladu, Sara, Conner, Elizabeth A., Seo, Daekwan, Hsieh, Jer-Tsong, Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2010

Hepatocyte Growth Factor (HGF)/c-Met Signaling is required for Stem Cell Mediated Liver Regeneration

Por Ishikawa, Tsuyoshi, Factor, Valentina M., Marquardt, Jens U., Raggi, Chiara, Seo, Daekwan, Kitade, Mitsuteru, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2012

Loss of c-Met Disrupts Gene Expression Program Required for G2/M Progression during Liver Regeneration in Mice

Por Factor, Valentina M., Seo, Daekwan, Ishikawa, Tsuyoshi, Kaposi-Novak, Pal, Marquardt, Jens U., Andersen, Jesper B., Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2010

An integrated genomic and pharmacoepigenomic approach predicts therapeutic response of zebularine in human liver cancer

Por Andersen, Jesper B., Factor, Valentina M., Marquardt, Jens U., Raggi, Chiara, Lee, Yun-Han, Seo, Daekwan, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Publicado em 2010

Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma

Por Calvisi, Diego F., Ladu, Sara, Gorden, Alexis, Farina, Miriam, Lee, Ju-Seog, Conner, Elizabeth A., Schroeder, Insa, Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2007

Contribution of hepatic lineage stage-specific donor memory to the differential potential of induced mouse pluripotent stem cells (iPSC)

Por Lee, Seung Bum, Seo, Daekwan, Choi, Dongho, Park, Kye-Yoon, Holczbauer, Agnes, Marquardt, Jens U., Conner, Elizabeth A., Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2012

MYC activates stem-like cell potential in hepatocarcinoma by a p53-dependent mechanism

Por Akita, Hirofumi, Marquardt, Jens U., Durkin, Marian E., Kitade, Mitsuteru, Seo, Daekwan, Conner, Elizabeth A., Andersen, Jesper B., Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2014

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

Por Kaposi-Novak, Pal, Libbrecht, Louis, Woo, Hyun-Goo, Lee, Yun-Han, Sears, Nathaniel C., Conner, Elizabeth A., Factor, Valentina M., Roskams, Tania, Thorgeirsson, Snorri S.
Publicado em 2009

The Transcription Factor GTF2IRD1 Regulates the Topology and Function of Photoreceptors by Modulating Photoreceptor Gene Expression across the Retina

Por Masuda, Tomohiro, Zhang, Xiaodong, Berlinicke, Cindy, Wan, Jun, Yerrabelli, Anitha, Conner, Elizabeth A., Kjellstrom, Sten, Bush, Ronald, Thorgeirsson, Snorri S., Swaroop, Anand, Chen, Shiming, Zack, Donald J.
Publicado no J Neurosci (2014)

Loss of c-Met Accelerates Development of Liver Fibrosis in Response to CCl(4) Exposure through Deregulation of Multiple Molecular Pathways

Por Marquardt, Jens U, Seo, Daekwan, Gomez-Quiroz, Luis E, Uchida, Koichi, Gillen, Matthew C, Kitade, Mitsuteru, Kaposi-Novak, Pal, Conner, Elizabeth A, Factor, Valentina M, Thorgeirsson, Snorri S
Publicado em 2012

Sequential transcriptome analysis of human liver cancer indicates late stage acquisition of malignant traits

Por Marquardt, Jens U., Seo, Daekwan, Andersen, Jesper B., Gillen, Matthew C., Kim, Myoung Soo, Conner, Elizabeth A., Galle, Peter R., Factor, Valentina M., Park, Young Nyun, Thorgeirsson, Snorri S.
Publicado em 2013

Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors

Por Andersen, Jesper B., Spee, Bart, Blechacz, Boris R., Avital, Itzhak, Komuta, Mina, Barbour, Andrew, Conner, Elizabeth A., Gillen, Matthew C., Roskams, Tania, Roberts, Lewis R., Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2011

Human Hepatic Cancer Stem Cells are Characterized by Common Stemness Traits and Diverse Oncogenic Pathways

Por Marquardt, Jens U., Raggi, Chiara, Andersen, Jesper B., Seo, Daekwan, Avital, Itzhak, Geller, David, Lee, Yun-Han, Kitade, Mitsuteru, Holczbauer, Agnes, Gillen, Matthew C., Conner, Elizabeth A., Factor, Valentina M., Thorgeirsson, Snorri S.
Publicado em 2011

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

Por Kitade, Mitsuteru, Factor, Valentina M., Andersen, Jesper B., Tomokuni, Akira, Kaji, Kosuke, Akita, Hirofumi, Holczbauer, Agnes, Seo, Daekwan, Marquardt, Jens U., Conner, Elizabeth A., Lee, Seung-Bum, Lee, Yun-Han, Thorgeirsson, Snorri S.
Publicado em 2013

Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress

Por Gomez-Quiroz, Luis E., Seo, Daekwan, Lee, Yun-Han, Kitade, Mitsuteru, Gaiser, Timo, Gillen, Matthew, Lee, Seung-Bum, Gutierrez-Ruiz, Ma Concepcion, Conner, Elizabeth A., Factor, Valentina M, Thorgeirsson, Snorri S., Marquardt, Jens U.
Publicado no Toxicology (2016)

mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

Por Thomas, Hala Elnakat, Mercer, Carol A., Carnevalli, Larissa S., Park, Jongsun, Andersen, Jesper B., Conner, Elizabeth A., Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J., Manway, Liu, Maira, S. Michel, Thorgeirsson, Snorri S., Mischel, Paul S., Thomas, George, Kozma, Sara C.
Publicado em 2012