Hepatocyte Growth Factor (HGF)/c-Met Signaling is required for Stem Cell Mediated Liver Regeneration

HGF/c-Met supports a pleiotrophic signal transduction pathway that controls stem cell homeostasis. Here, we directly addressed the role of c-Met in stem cell-mediated liver regeneration by utilizing mice harboring c-met floxed alleles and Alb-Cre or Mx1-Cre transgenes. To activate oval cells, the he...

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Detalhes bibliográficos
Main Authors: Ishikawa, Tsuyoshi, Factor, Valentina M., Marquardt, Jens U., Raggi, Chiara, Seo, Daekwan, Kitade, Mitsuteru, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299882/
https://ncbi.nlm.nih.gov/pubmed/22095660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24796
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