Loss of c-Met signaling sensitizes hepatocytes to lipotoxicity and induces cholestatic liver damage by aggravating oxidative stress

Recent studies confirmed a critical importance of c-Met signaling for liver regeneration by modulating redox balance. Here we used liver-specific conditional knockout mice (MetKO) and a nutritional model of hepatic steatosis to address the role of c-Met in cholesterol-mediated liver toxicity. Liver...

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Publicado en:Toxicology
Autores principales: Gomez-Quiroz, Luis E., Seo, Daekwan, Lee, Yun-Han, Kitade, Mitsuteru, Gaiser, Timo, Gillen, Matthew, Lee, Seung-Bum, Gutierrez-Ruiz, Ma Concepcion, Conner, Elizabeth A., Factor, Valentina M, Thorgeirsson, Snorri S., Marquardt, Jens U.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131870/
https://ncbi.nlm.nih.gov/pubmed/27394961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.07.004
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