Hepatocyte-specific c-Met Deletion Disrupts Redox Homeostasis and Sensitizes to Fas-mediated Apoptosis

The hepatocyte growth factor and its receptor c-Met direct a pleiotropic signal transduction pathway that controls cell survival. We previously demonstrated that mice lacking c-Met (Met-KO) in hepatocytes were hypersensitive to Fas-induced liver injury. In this study, we used primary hepatocytes iso...

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Bibliografiset tiedot
Päätekijät: Gómez-Quiroz, Luis E., Factor, Valentina M., Kaposi-Novak, Pal, Coulouarn, Cedric, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Mechanisms of Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386934/
https://ncbi.nlm.nih.gov/pubmed/18348981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707733200
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