Loss of c-Met Disrupts Gene Expression Program Required for G2/M Progression during Liver Regeneration in Mice

BACKGROUND: Previous work has established that HGF/c-Met signaling plays a pivotal role in regulating the onset of S phase following partial hepatectomy (PH). In this study, we used Met(fl/fl);Alb-Cre(+/−) conditional knockout mice to determine the effects of c-Met dysfunction in hepatocytes on kine...

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Detalhes bibliográficos
Main Authors: Factor, Valentina M., Seo, Daekwan, Ishikawa, Tsuyoshi, Kaposi-Novak, Pal, Marquardt, Jens U., Andersen, Jesper B., Conner, Elizabeth A., Thorgeirsson, Snorri S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940888/
https://ncbi.nlm.nih.gov/pubmed/20862286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012739
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