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An integrated genomic and pharmacoepigenomic approach predicts therapeutic response of zebularine in human liver cancer
Epigenomic changes such as aberrant hypermethylation and subsequent atypical gene silencing are characteristic features of human cancer. Here, we report a comprehensive characterization of epigenomic modulation caused by zebularine, an effective DNA methylation inhibitor, in human liver cancer. Usin...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077922/ https://ncbi.nlm.nih.gov/pubmed/20962331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001338 |
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