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An integrated genomic and pharmacoepigenomic approach predicts therapeutic response of zebularine in human liver cancer
Epigenomic changes such as aberrant hypermethylation and subsequent atypical gene silencing are characteristic features of human cancer. Here, we report a comprehensive characterization of epigenomic modulation caused by zebularine, an effective DNA methylation inhibitor, in human liver cancer. Usin...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3077922/ https://ncbi.nlm.nih.gov/pubmed/20962331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001338 |
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