An integrated genomic and pharmacoepigenomic approach predicts therapeutic response of zebularine in human liver cancer

Epigenomic changes such as aberrant hypermethylation and subsequent atypical gene silencing are characteristic features of human cancer. Here, we report a comprehensive characterization of epigenomic modulation caused by zebularine, an effective DNA methylation inhibitor, in human liver cancer. Usin...

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Detaylı Bibliyografya
Asıl Yazarlar: Andersen, Jesper B., Factor, Valentina M., Marquardt, Jens U., Raggi, Chiara, Lee, Yun-Han, Seo, Daekwan, Conner, Elizabeth A., Thorgeirsson, Snorri S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3077922/
https://ncbi.nlm.nih.gov/pubmed/20962331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001338
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