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E2F1 Inhibits c-Myc-driven Apoptosis via PIK3CA/Akt/mTOR and COX-2 in a Mouse Model of Human Liver Cancer
BACKGROUND & AIMS: Resistance to apoptosis is essential for cancer growth. We previously reported that hepatic co-expression of c-Myc and E2F1, two key regulators of proliferation and apoptosis, enhanced HCC development in transgenic mice. Here, we investigated the molecular mechanisms underlyin...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2614075/ https://ncbi.nlm.nih.gov/pubmed/18722373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2008.07.012 |
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