Ganglioneuromas are driven by activated AKT and can be therapeutically targeted with mTOR inhibitors

Peripheral sympathetic nervous system tumors are the most common extracranial solid tumors of childhood and include neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. Surgery is the only effective therapy for ganglioneuroma, which may be challenging due to the location of the tumor and involve...

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Detalles Bibliográficos
Publicado en:J Exp Med
Main Authors: Tao, Ting, Shi, Hui, Wang, Meng, Perez-Atayde, Antonio R., London, Wendy B., Gutierrez, Alejandro, Lemos, Bernardo, Durbin, Adam D., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Rockefeller University Press 2020
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7537400/
https://ncbi.nlm.nih.gov/pubmed/32728700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191871
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