Targeting ganglioneuromas with mTOR inhibitors

We recently identified activated protein kinase B (PKB/AKT) as a tumorigenic driver in childhood ganglioneuroma. Inhibition of the mechanistic target of rapamycin (mTOR), a serine/threonine kinase downstream of AKT, effectively reduced the tumor burden in zebrafish with ganglioneuroma. We propose a...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: Tao, Ting, Shi, Hui, Durbin, Adam D., Look, A. Thomas
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7849689/
https://ncbi.nlm.nih.gov/pubmed/33553609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1856621
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