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PIK3CA/PTEN Mutations and Akt Activation as Markers of Sensitivity to Allosteric mTOR inhibitors
PURPOSE: We sought to determine whether PI3K pathway mutation or activation state and rapamycin-induced feedback-loop activation of Akt is associated with rapamycin sensitivity or resistance. EXPERIMENTAL DESIGN: Cancer cell lines were tested for rapamycin-sensitivity, Akt phosphorylation and mTOR t...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3307149/ https://ncbi.nlm.nih.gov/pubmed/22422409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2123 |
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