PIK3CA/PTEN Mutations and Akt Activation as Markers of Sensitivity to Allosteric mTOR inhibitors

PURPOSE: We sought to determine whether PI3K pathway mutation or activation state and rapamycin-induced feedback-loop activation of Akt is associated with rapamycin sensitivity or resistance. EXPERIMENTAL DESIGN: Cancer cell lines were tested for rapamycin-sensitivity, Akt phosphorylation and mTOR t...

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Autores principales: Meric-Bernstam, Funda, Akcakanat, Argun, Chen, Huiqin, Do, Kim-Anh, Sangai, Takafumi, Adkins, Farrell, Gonzalez-Angulo, Ana Maria, Rashid, Asif, Crosby, Katherine, Dong, Mei, Phan, Alexandria T., Wolff, Robert A., Gupta, Sanjay, Mills, Gordon B., Yao, James
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307149/
https://ncbi.nlm.nih.gov/pubmed/22422409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2123
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