mTOR Inhibitors Synergize on Regression, Reversal of Gene Expression, and Autophagy in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) affects more than half a million people worldwide and is the third most common cause of cancer deaths. Because mammalian target of rapamycin (mTOR) signaling is up-regulated in 50% of HCCs, we compared the effects of the U.S. Food and Drug Administration–approved mTOR-...

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Hauptverfasser: Thomas, Hala Elnakat, Mercer, Carol A., Carnevalli, Larissa S., Park, Jongsun, Andersen, Jesper B., Conner, Elizabeth A., Tanaka, Kazuhiro, Matsutani, Tomoo, Iwanami, Akio, Aronow, Bruce J., Manway, Liu, Maira, S. Michel, Thorgeirsson, Snorri S., Mischel, Paul S., Thomas, George, Kozma, Sara C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3703151/
https://ncbi.nlm.nih.gov/pubmed/22539746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3003923
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