Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

Por Ayton, Scott, Lei, Peng, Adlard, Paul A, Volitakis, Irene, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I
Publicado em 2014

Mechanisms of Copper Ion Mediated Huntington's Disease Progression

Por Fox, Jonathan H., Kama, Jibrin A., Lieberman, Gregory, Chopra, Raman, Dorsey, Kate, Chopra, Vanita, Volitakis, Irene, Cherny, Robert A., Bush, Ashley I., Hersch, Steven
Publicado em 2007

A novel approach to rapidly prevent age-related cognitive decline

Por Adlard, Paul A, Sedjahtera, Amelia, Gunawan, Lydia, Bray, Lisa, Hare, Dominic, Lear, Jessica, Doble, Philip, Bush, Ashley I, Finkelstein, David I, Cherny, Robert A
Publicado no Aging Cell (2014)

Zinc and Copper Modulate Alzheimer Aβ Levels in Human Cerebrospinal Fluid

Por Strozyk, Dorothea, Launer, Lenore J., Adlard, Paul A., Cherny, Robert A., Tsatsanis, Andrew, Volitakis, Irene, Blennow, Kaj, Petrovitch, Helen, White, Lon R., Bush, Ashley I.
Publicado em 2007

Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction

Por Rembach, Alan, Hare, Dominic J., Lind, Monica, Fowler, Christopher J., Cherny, Robert A., McLean, Catriona, Bush, Ashley I., Masters, Colin L., Roberts, Blaine R.
Publicado em 2013

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

Por Gunn, Adam P., Wong, Bruce X., Johanssen, Timothy, Griffith, James C., Masters, Colin L., Bush, Ashley I., Barnham, Kevin J., Duce, James A., Cherny, Robert A.
Publicado no J Biol Chem (2016)

The Caenorhabditis elegans Aβ(1–42) Model of Alzheimer Disease Predominantly Expresses Aβ(3–42)

Por McColl, Gawain, Roberts, Blaine R., Gunn, Adam P., Perez, Keyla A., Tew, Deborah J., Masters, Colin L., Barnham, Kevin J., Cherny, Robert A., Bush, Ashley I.
Publicado em 2009

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions: IMPLICATIONS FOR ALZHEIMER DISEASE

Por Hung, Ya Hui, Robb, Elysia L., Volitakis, Irene, Ho, Michael, Evin, Genevieve, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin L., Cherny, Robert A., Bush, Ashley I.
Publicado em 2009

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

Por Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C
Publicado em 2009

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

Por Puglielli, Luigi, Friedlich, Avi L., Setchell, Kenneth D.R., Nagano, Seiichi, Opazo, Carlos, Cherny, Robert A., Barnham, Kevin J., Wade, John D., Melov, Simon, Kovacs, Dora M., Bush, Ashley I.
Publicado em 2005

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

Por Puglielli, Luigi, Friedlich, Avi L., Setchell, Kenneth D.R., Nagano, Seiichi, Opazo, Carlos, Cherny, Robert A., Barnham, Kevin J., Wade, John D., Melov, Simon, Kovacs, Dora M., Bush, Ashley I.
Publicado em 2006

Utility of an improved model of amyloid-beta (Aβ(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

Por McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A
Publicado em 2012

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

Por Fox, Jonathan H., Connor, Teal, Stiles, Megan, Kama, Jibrin, Lu, Zhen, Dorsey, Kathryn, Liebermann, Gregory, Sapp, Ellen, Cherny, Robert A., Banks, Mary, Volitakis, Irene, DiFiglia, Marian, Berezovska, Oksana, Bush, Ashley I., Hersch, Steven M.
Publicado em 2011

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.

Por Fox, Jonathan H., Connor, Teal, Stiles, Megan, Kama, Jibrin, Lu, Zhen, Dorsey, Kathryn, Lieberman, Gregory, Sapp, Ellen, Cherny, Robert A., Banks, Mary, Volitakis, Irene, DiFiglia, Marian, Berezovska, Oksana, Bush, Ashley I., Hersch, Steven M.
Publicado em 2011

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Por Melov, Simon, Adlard, Paul A., Morten, Karl, Johnson, Felicity, Golden, Tamara R., Hinerfeld, Doug, Schilling, Birgit, Mavros, Christine, Masters, Colin L., Volitakis, Irene, Li, Qiao-Xin, Laughton, Katrina, Hubbard, Alan, Cherny, Robert A., Gibson, Brad, Bush, Ashley I.
Publicado em 2007

Differential modulation of Alzheimer's disease amyloid β-peptide accumulation by diverse classes of metal ligands

Por Caragounis, Aphrodite, Du, Tai, Filiz, Gulay, Laughton, Katrina M., Volitakis, Irene, Sharples, Robyn A., Cherny, Robert A., Masters, Colin L., Drew, Simon C., Hill, Andrew F., Li, Qiao-Xin, Crouch, Peter J., Barnham, Kevin J., White, Anthony R.
Publicado em 2007

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition A TARGET FOR NEUROPROTECTION IN THE CENTRAL NERVOUS SYSTEM

Por Siddiq, Ambreena, Ayoub, Issam A., Chavez, Juan C., Aminova, Leila, Shah, Sapan, LaManna, Joseph C., Patton, Stephanie M., Connor, James R., Cherny, Robert A., Volitakis, Irene, Bush, Ashley I., Langsetmo, Ingrid, Seeley, Todd, Gunzler, Volkmar, Ratan, Rajiv R.
Publicado em 2005

Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease

Por Barnham, Kevin J., Kenche, Vijaya B., Ciccotosto, Giuseppe D., Smith, David P., Tew, Deborah J., Liu, Xiang, Perez, Keyla, Cranston, Greg A., Johanssen, Timothy J., Volitakis, Irene, Bush, Ashley I., Masters, Colin L., White, Anthony R., Smith, Jeffrey P., Cherny, Robert A., Cappai, Roberto
Publicado em 2008

Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

Por Crouch, Peter J., Hung, Lin Wai, Adlard, Paul A., Cortes, Mikhalina, Lal, Varsha, Filiz, Gulay, Perez, Keyla A., Nurjono, Milawaty, Caragounis, Aphrodite, Du, Tai, Laughton, Katrina, Volitakis, Irene, Bush, Ashley I., Li, Qiao-Xin, Masters, Colin L., Cappai, Roberto, Cherny, Robert A., Donnelly, Paul S., White, Anthony R., Barnham, Kevin J.
Publicado em 2009

The hypoxia imaging agent Cu(II)(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

Por Hung, Lin W., Villemagne, Victor L., Cheng, Lesley, Sherratt, Nicki A., Ayton, Scott, White, Anthony R., Crouch, Peter J., Lim, SinChun, Leong, Su Ling, Wilkins, Simon, George, Jessica, Roberts, Blaine R., Pham, Chi L.L., Liu, Xiang, Chiu, Francis C.K., Shackleford, David M., Powell, Andrew K., Masters, Colin L., Bush, Ashley I., O’Keefe, Graeme, Culvenor, Janetta G., Cappai, Roberto, Cherny, Robert A., Donnelly, Paul S., Hill, Andrew F., Finkelstein, David I., Barnham, Kevin J.
Publicado em 2012