Utility of an improved model of amyloid-beta (Aβ(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

BACKGROUND: The definitive indicator of Alzheimer’s disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have been proposed for high throughput drug screening for potential therapeutic benefit in diseases of protein misfolding....

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Detalhes bibliográficos
Main Authors: McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3519830/
https://ncbi.nlm.nih.gov/pubmed/23171715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-57
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