Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

BACKGROUND: The amyloid β-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The intrinsic and external/environmental factors that determine Aβ aggregation in vivo are poorly understood, as well as the cellular meaning of...

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Detalhes bibliográficos
Main Authors: Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2632641/
https://ncbi.nlm.nih.gov/pubmed/19126228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-4-2
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