Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

por Ayton, Scott, Lei, Peng, Adlard, Paul A, Volitakis, Irene, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I
Publicado 2014

Genetically Decreased Spinal Cord Copper Concentration Prolongs Life in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

por Kiaei, Mahmoud, Bush, Ashley I., Morrison, Brett M., Morrison, John H., Cherny, Robert A., Volitakis, Irene, Beal, M. Flint, Gordon, Jon W.
Publicado en J Neurosci (2004)

Mechanisms of Copper Ion Mediated Huntington's Disease Progression

por Fox, Jonathan H., Kama, Jibrin A., Lieberman, Gregory, Chopra, Raman, Dorsey, Kate, Chopra, Vanita, Volitakis, Irene, Cherny, Robert A., Bush, Ashley I., Hersch, Steven
Publicado 2007

A novel approach to rapidly prevent age-related cognitive decline

por Adlard, Paul A, Sedjahtera, Amelia, Gunawan, Lydia, Bray, Lisa, Hare, Dominic, Lear, Jessica, Doble, Philip, Bush, Ashley I, Finkelstein, David I, Cherny, Robert A
Publicado en Aging Cell (2014)

Zinc and Copper Modulate Alzheimer Aβ Levels in Human Cerebrospinal Fluid

por Strozyk, Dorothea, Launer, Lenore J., Adlard, Paul A., Cherny, Robert A., Tsatsanis, Andrew, Volitakis, Irene, Blennow, Kaj, Petrovitch, Helen, White, Lon R., Bush, Ashley I.
Publicado 2007

Decreased Copper in Alzheimer's Disease Brain Is Predominantly in the Soluble Extractable Fraction

por Rembach, Alan, Hare, Dominic J., Lind, Monica, Fowler, Christopher J., Cherny, Robert A., McLean, Catriona, Bush, Ashley I., Masters, Colin L., Roberts, Blaine R.
Publicado 2013

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

por Gunn, Adam P., Wong, Bruce X., Johanssen, Timothy, Griffith, James C., Masters, Colin L., Bush, Ashley I., Barnham, Kevin J., Duce, James A., Cherny, Robert A.
Publicado en J Biol Chem (2016)

Neuronal Zinc Exchange with the Blood Vessel Wall Promotes Cerebral Amyloid Angiopathy in an Animal Model of Alzheimer's Disease

por Friedlich, Avi L., Lee, Joo-Yong, van Groen, Thomas, Cherny, Robert A., Volitakis, Irene, Cole, Toby B., Palmiter, Richard D., Koh, Jae-Young, Bush, Ashley I.
Publicado en J Neurosci (2004)

The Caenorhabditis elegans Aβ(1–42) Model of Alzheimer Disease Predominantly Expresses Aβ(3–42)

por McColl, Gawain, Roberts, Blaine R., Gunn, Adam P., Perez, Keyla A., Tew, Deborah J., Masters, Colin L., Barnham, Kevin J., Cherny, Robert A., Bush, Ashley I.
Publicado 2009

Paradoxical Condensation of Copper with Elevated β-Amyloid in Lipid Rafts under Cellular Copper Deficiency Conditions: IMPLICATIONS FOR ALZHEIMER DISEASE

por Hung, Ya Hui, Robb, Elysia L., Volitakis, Irene, Ho, Michael, Evin, Genevieve, Li, Qiao-Xin, Culvenor, Janetta G., Masters, Colin L., Cherny, Robert A., Bush, Ashley I.
Publicado 2009

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

por Minniti, Alicia N, Rebolledo, Daniela L, Grez, Paula M, Fadic, Ricardo, Aldunate, Rebeca, Volitakis, Irene, Cherny, Robert A, Opazo, Carlos, Masters, Colin, Bush, Ashley I, Inestrosa, Nibaldo C
Publicado 2009

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

por James, Simon A., Roberts, Blaine R., Hare, Dominic J., de Jonge, Martin D., Birchall, Ian E., Jenkins, Nicole L., Cherny, Robert A., Bush, Ashley I., McColl, Gawain
Publicado en Chem Sci (2015)

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

por Puglielli, Luigi, Friedlich, Avi L., Setchell, Kenneth D.R., Nagano, Seiichi, Opazo, Carlos, Cherny, Robert A., Barnham, Kevin J., Wade, John D., Melov, Simon, Kovacs, Dora M., Bush, Ashley I.
Publicado 2005

Alzheimer disease β-amyloid activity mimics cholesterol oxidase

por Puglielli, Luigi, Friedlich, Avi L., Setchell, Kenneth D.R., Nagano, Seiichi, Opazo, Carlos, Cherny, Robert A., Barnham, Kevin J., Wade, John D., Melov, Simon, Kovacs, Dora M., Bush, Ashley I.
Publicado 2006

Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage

por Diomede, Luisa, Romeo, Margherita, Rognoni, Paola, Beeg, Marten, Foray, Claudia, Ghibaudi, Elena, Palladini, Giovanni, Cherny, Robert A., Verga, Laura, Capello, Gian Luca, Perfetti, Vittorio, Fiordaliso, Fabio, Merlini, Giampaolo, Salmona, Mario
Publicado en Antioxid Redox Signal (2017)

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of β-Amyloid Precursor Protein

por Ayton, Scott, Lei, Peng, Hare, Dominic J., Duce, James A., George, Jessica L., Adlard, Paul A., McLean, Catriona, Rogers, Jack T., Cherny, Robert A., Finkelstein, David I., Bush, Ashley I.
Publicado en J Neurosci (2015)

Utility of an improved model of amyloid-beta (Aβ(1-42)) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

por McColl, Gawain, Roberts, Blaine R, Pukala, Tara L, Kenche, Vijaya B, Roberts, Christine M, Link, Christopher D, Ryan, Timothy M, Masters, Colin L, Barnham, Kevin J, Bush, Ashley I, Cherny, Robert A
Publicado 2012

Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β(1-)42

por Crouch, Peter J., Blake, Rachel, Duce, James A., Ciccotosto, Giuseppe D., Li, Qiao-Xin, Barnham, Kevin J., Curtain, Cyril C., Cherny, Robert A., Cappai, Roberto, Dyrks, Thomas, Masters, Colin L., Trounce, Ian A.
Publicado en J Neurosci (2005)

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

por Fox, Jonathan H., Connor, Teal, Stiles, Megan, Kama, Jibrin, Lu, Zhen, Dorsey, Kathryn, Liebermann, Gregory, Sapp, Ellen, Cherny, Robert A., Banks, Mary, Volitakis, Irene, DiFiglia, Marian, Berezovska, Oksana, Bush, Ashley I., Hersch, Steven M.
Publicado 2011

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.

por Fox, Jonathan H., Connor, Teal, Stiles, Megan, Kama, Jibrin, Lu, Zhen, Dorsey, Kathryn, Lieberman, Gregory, Sapp, Ellen, Cherny, Robert A., Banks, Mary, Volitakis, Irene, DiFiglia, Marian, Berezovska, Oksana, Bush, Ashley I., Hersch, Steven M.
Publicado 2011