Copper-Dependent Inhibition of Human Cytochrome c Oxidase by a Dimeric Conformer of Amyloid-β(1-)42

In studies of Alzheimer's disease pathogenesis there is an increasing focus on mechanisms of intracellular amyloid-β (Aβ) generation and toxicity. Here we investigated the inhibitory potential of the 42 amino acid Aβ peptide (Aβ(1-42)) on activity of electron transport chain enzyme complexes in...

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Pubblicato in:J Neurosci
Autori principali: Crouch, Peter J., Blake, Rachel, Duce, James A., Ciccotosto, Giuseppe D., Li, Qiao-Xin, Barnham, Kevin J., Curtain, Cyril C., Cherny, Robert A., Cappai, Roberto, Dyrks, Thomas, Masters, Colin L., Trounce, Ian A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2005
Soggetti:
Neurobiology of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6725334/
https://ncbi.nlm.nih.gov/pubmed/15659604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4276-04.2005
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