Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity

Alzheimer's disease is an age-related neurodegenerative disorder with its toxicity linked to the generation of amyloid-β peptide (Aβ). Within the Aβ sequence, there is a systemic repeat of a GxxxG motif, which theoretical studies have suggested may be involved in both peptide aggregation and me...

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Опубликовано в: :J Neurosci
Главные авторы: Hung, Lin Wai, Ciccotosto, Giuseppe D., Giannakis, Eleni, Tew, Deborah J., Perez, Keyla, Masters, Colin L., Cappai, Roberto, Wade, John D., Barnham, Kevin J.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671645/
https://ncbi.nlm.nih.gov/pubmed/19005060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3916-08.2008
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