Intrinsic Determinants of Neurotoxic Aggregate Formation by the Amyloid β Peptide

The extent to which proteins aggregate into distinct structures ranging from prefibrillar oligomers to amyloid fibrils is key to the pathogenesis of many age-related degenerative diseases. We describe here for the Alzheimer's disease-related amyloid β peptide (Aβ) an investigation of the sequen...

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Detalhes bibliográficos
Main Authors: Brorsson, Ann-Christin, Bolognesi, Benedetta, Tartaglia, Gian Gaetano, Shammas, Sarah L., Favrin, Giorgio, Watson, Ian, Lomas, David A., Chiti, Fabrizio, Vendruscolo, Michele, Dobson, Christopher M., Crowther, Damian C., Luheshi, Leila M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2010
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856165/
https://ncbi.nlm.nih.gov/pubmed/20409489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.12.4320
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