Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

Increasing evidence indicates that oligomeric protein assemblies may represent the molecular species responsible for cytotoxicity in a range of neurological disorders including Alzheimer and Parkinson diseases. We use all-atom computer simulations to reveal that the process of oligomerization can be...

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Bibliographic Details
Main Authors: Cheon, Mookyung, Chang, Iksoo, Mohanty, Sandipan, Luheshi, Leila M, Dobson, Christopher M, Vendruscolo, Michele, Favrin, Giorgio
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976335/
https://ncbi.nlm.nih.gov/pubmed/17941703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030173
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