Structural Reorganisation and Potential Toxicity of Oligomeric Species Formed during the Assembly of Amyloid Fibrils

Increasing evidence indicates that oligomeric protein assemblies may represent the molecular species responsible for cytotoxicity in a range of neurological disorders including Alzheimer and Parkinson diseases. We use all-atom computer simulations to reveal that the process of oligomerization can be...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cheon, Mookyung, Chang, Iksoo, Mohanty, Sandipan, Luheshi, Leila M, Dobson, Christopher M, Vendruscolo, Michele, Favrin, Giorgio
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2007
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976335/
https://ncbi.nlm.nih.gov/pubmed/17941703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030173
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