Expression in Drosophila of Tandem Amyloid β Peptides Provides Insights into Links between Aggregation and Neurotoxicity

The generation and subsequent aggregation of amyloid β (Aβ) peptides play a crucial initiating role in the pathogenesis of Alzheimer disease (AD). The two main isoforms of these peptides have 40 (Aβ(40)) or 42 residues (Aβ(42)), the latter having a higher propensity to aggregate in vitro and being t...

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Detalhes bibliográficos
Main Authors: Speretta, Elena, Jahn, Thomas R., Tartaglia, Gian Gaetano, Favrin, Giorgio, Barros, Teresa P., Imarisio, Sara, Lomas, David A., Luheshi, Leila M., Crowther, Damian C., Dobson, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370257/
https://ncbi.nlm.nih.gov/pubmed/22461632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.350124
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