Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

BACKGROUND: The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and pathologically in Parkinson’s disease (PD). Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export. We previously showed t...

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Detalhes bibliográficos
Main Authors: Ayton, Scott, Lei, Peng, Adlard, Paul A, Volitakis, Irene, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114139/
https://ncbi.nlm.nih.gov/pubmed/25011704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-27
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