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Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a polyglutamine-encoding CAG expansion in the huntingtin gene. Iron accumulates in the brains of HD patients and mouse disease models. However, the cellular and subcellular sites of iron accumulation, as well as signific...

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Main Authors: Chen, Jianfang, Marks, Eileen, Lai, Barry, Zhang, Zhaojie, Duce, James A., Lam, Linh Q., Volitakis, Irene, Bush, Ashley I., Hersch, Steven, Fox, Jonathan H.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3795666/
https://ncbi.nlm.nih.gov/pubmed/24146952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0077023
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