Amyloid precursor protein haploinsufficiency preferentially mediates brain iron accumulation in mice transgenic for the Huntington’s disease mutation.

BACKGROUND: Huntington’s disease (HD) is an autosomal dominant disorder caused by a CAG expansion in the huntingtin gene that results in expression of mutant huntingtin protein. Iron accumulates in HD brain neurons. Amyloid precursor protein (APP) promotes neuronal iron export. However, the role of...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Huntingtons Dis
Autori principali: Berggren, Kiersten, Agrawal, Sonal, Fox, Julia A., Hildenbrand, Justin, Nelson, Ryan, Bush, Ashley I., Fox, Jonathan H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594052/
https://ncbi.nlm.nih.gov/pubmed/28550267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170242
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi