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Amyloid precursor protein haploinsufficiency preferentially mediates brain iron accumulation in mice transgenic for the Huntington’s disease mutation.
BACKGROUND: Huntington’s disease (HD) is an autosomal dominant disorder caused by a CAG expansion in the huntingtin gene that results in expression of mutant huntingtin protein. Iron accumulates in HD brain neurons. Amyloid precursor protein (APP) promotes neuronal iron export. However, the role of...
Uloženo v:
| Vydáno v: | J Huntingtons Dis |
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| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6594052/ https://ncbi.nlm.nih.gov/pubmed/28550267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JHD-170242 |
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