Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion that encodes a polyglutamine tract in huntingtin (htt) protein. Dysregulation of brain iron homeostasis, oxidative stress and neurodegeneration are consistent features of the HD phenotype. Therefor...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Berggren, Kiersten L., Chen, Jianfang, Fox, Julia, Miller, Jonathan, Dodds, Lindsay, Dugas, Bryan, Vargas, Liset, Lothian, Amber, McAllum, Erin, Volitakis, Irene, Roberts, Blaine, Bush, Ashley I., Fox, Jonathan H.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348428/
https://ncbi.nlm.nih.gov/pubmed/25703232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.02.002
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