Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson’s disease

BACKGROUND: The substantia nigra (SN) midbrain nucleus is constitutively iron rich. Iron levels elevate further with age, and pathologically in Parkinson’s disease (PD). Iron accumulation in PD SN involves dysfunction of ceruloplasmin (CP), which normally promotes iron export. We previously showed t...

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Autors principals: Ayton, Scott, Lei, Peng, Adlard, Paul A, Volitakis, Irene, Cherny, Robert A, Bush, Ashley I, Finkelstein, David I
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Short Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4114139/
https://ncbi.nlm.nih.gov/pubmed/25011704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-27
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