Zinc and Copper Modulate Alzheimer Aβ Levels in Human Cerebrospinal Fluid

Abnormal interaction of β-amyloid 42 (Aβ42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Aβ degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinas...

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Главные авторы: Strozyk, Dorothea, Launer, Lenore J., Adlard, Paul A., Cherny, Robert A., Tsatsanis, Andrew, Volitakis, Irene, Blennow, Kaj, Petrovitch, Helen, White, Lon R., Bush, Ashley I.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709821/
https://ncbi.nlm.nih.gov/pubmed/18068270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2007.10.012
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