Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition A TARGET FOR NEUROPROTECTION IN THE CENTRAL NERVOUS SYSTEM

Hypoxia-inducible factor (HIF) prolyl 4-hydroxylases are a family of iron- and 2-oxoglutarate-dependent dioxygenases that negatively regulate the stability of several proteins that have established roles in adaptation to hypoxic or oxidative stress. These proteins include the transcriptional activat...

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Detalhes bibliográficos
Main Authors: Siddiq, Ambreena, Ayoub, Issam A., Chavez, Juan C., Aminova, Leila, Shah, Sapan, LaManna, Joseph C., Patton, Stephanie M., Connor, James R., Cherny, Robert A., Volitakis, Irene, Bush, Ashley I., Langsetmo, Ingrid, Seeley, Todd, Gunzler, Volkmar, Ratan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2586128/
https://ncbi.nlm.nih.gov/pubmed/16227210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M504963200
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