Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

Oxidative stress contributes to tissue injury in conditions ranging from cardiovascular disease to stroke, spinal cord injury, neurodegeneration, and perhaps even aging. Yet the efficacy of antioxidants in human disease has been mixed at best. We need a better understanding of the mechanisms by whic...

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Detalhes bibliográficos
Main Authors: Siddiq, Ambreena, Aminova, Leila R., Troy, Carol M., Suh, Kyungsun, Messer, Zachary, Semenza, Gregg L., Ratan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290095/
https://ncbi.nlm.nih.gov/pubmed/19587290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1779-09.2009
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