OXYGEN-SENSITIVE RESET OF INDUCIBLE HIF TRANSACTIVATION RESPONSE: PROLYL HYDROXYLASES TUNE THE BIOLOGICAL NORMOXIC SETPOINT

Cellular O(2) sensing enables physiological adjustments to variations in tissue pO(2). Under basal conditions, cells are adjusted to an O(2) environment biologically read as normoxia. Any sharp departure from that state of normoxia triggers O(2)-sensitive biological responses. The stabilization of h...

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Bibliographic Details
Main Authors: Khanna, Savita, Roy, Sashwati, Maurer, Mariah, Ratan, Rajiv R, Sen, Chandan K
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489266/
https://ncbi.nlm.nih.gov/pubmed/16785028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.02.010
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