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Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease

Amelyoid-β peptide (Aβ) is a major causative agent responsible for Alzheimer's disease (AD). Aβ contains a high affinity metal binding site that modulates peptide aggregation and toxicity. Therefore, identifying molecules targeting this site represents a valid therapeutic strategy. To test this...

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Detalhes bibliográficos
Main Authors: Barnham, Kevin J., Kenche, Vijaya B., Ciccotosto, Giuseppe D., Smith, David P., Tew, Deborah J., Liu, Xiang, Perez, Keyla, Cranston, Greg A., Johanssen, Timothy J., Volitakis, Irene, Bush, Ashley I., Masters, Colin L., White, Anthony R., Smith, Jeffrey P., Cherny, Robert A., Cappai, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383936/
https://ncbi.nlm.nih.gov/pubmed/18463291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800712105
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