Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer's disease

Amelyoid-β peptide (Aβ) is a major causative agent responsible for Alzheimer's disease (AD). Aβ contains a high affinity metal binding site that modulates peptide aggregation and toxicity. Therefore, identifying molecules targeting this site represents a valid therapeutic strategy. To test this...

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Main Authors: Barnham, Kevin J., Kenche, Vijaya B., Ciccotosto, Giuseppe D., Smith, David P., Tew, Deborah J., Liu, Xiang, Perez, Keyla, Cranston, Greg A., Johanssen, Timothy J., Volitakis, Irene, Bush, Ashley I., Masters, Colin L., White, Anthony R., Smith, Jeffrey P., Cherny, Robert A., Cappai, Roberto
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383936/
https://ncbi.nlm.nih.gov/pubmed/18463291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800712105
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