UbcH7 reactivity profile reveals Parkin and HHARI to be RING/HECT hybrids

Por Wenzel, Dawn M., Lissounov, Alexei, Brzovic, Peter S., Klevit, Rachel E.
Publicado em 2011

Biochemical and Structural Characterization of the Ubiquitin-Conjugating Enzyme UBE2W Reveals the Formation of a Noncovalent Homodimer

Por Vittal, Vinayak, Wenzel, Dawn M., Brzovic, Peter S., Klevit, Rachel E.
Publicado em 2013

Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

Por Vittal, Vinayak, Stewart, Mikaela D., Brzovic, Peter S., Klevit, Rachel E.
Publicado no J Biol Chem (2015)

E2 enzymes: more than just middle men

Por Stewart, Mikaela D, Ritterhoff, Tobias, Klevit, Rachel E, Brzovic, Peter S
Publicado no Cell Res (2016)

The Essential Ubc4/Ubc5 Function in Yeast Is HECT E3-dependent, and RING E3-dependent Pathways Require Only Monoubiquitin Transfer by Ubc4

Por Stoll, Kate E., Brzovic, Peter S., Davis, Trisha N., Klevit, Rachel E.
Publicado em 2011

Ubiquitin in Motion: Structural studies of the E2~Ub conjugate

Por Pruneda, Jonathan N., Stoll, Kate E., Bolton, Laura J., Brzovic, Peter S., Klevit, Rachel E.
Publicado em 2011

A Salmonella typhimurium-translocated Glycerophospholipid:Cholesterol Acyltransferase Promotes Virulence by Binding to the RhoA Protein Switch Regions

Por LaRock, Doris L., Brzovic, Peter S., Levin, Itay, Blanc, Marie-Pierre, Miller, Samuel I.
Publicado em 2012

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

Por DeBerg, Hannah A., Brzovic, Peter S., Flynn, Galen E., Zagotta, William N., Stoll, Stefan
Publicado no J Biol Chem (2016)

Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences

Por Fox, David, Le Trong, Isolde, Rajagopal, Ponni, Brzovic, Peter S., Stenkamp, Ronald E., Klevit, Rachel E.
Publicado em 2008

Identification of an unconventional E3 binding surface on the UbcH5 ∼ Ub conjugate recognized by a pathogenic bacterial E3 ligase.

Por Levin, Itay, Eakin, Catherine, Blanc, Marie-Pierre, Klevit, Rachel E., Miller, Samuel I., Brzovic, Peter S.
Publicado em 2010

The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation

Por Cook, Matt, Delbecq, Scott P., Schweppe, Thomas P., Guttman, Miklos, Klevit, Rachel E., Brzovic, Peter S.
Publicado no J Biol Chem (2019)

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

Por Brzovic, Peter S., Keeffe, Jennifer R., Nishikawa, Hiroyuki, Miyamoto, Keiko, Fox, David, Fukuda, Mamoru, Ohta, Tomohiko, Klevit, Rachel
Publicado em 2003

Structural mechanism for the regulation of HCN ion channels by the accessory protein TRIP8b

Por DeBerg, Hannah A., Bankston, John R., Rosenbaum, Joel C., Brzovic, Peter S., Zagotta, William N., Stoll, Stefan
Publicado no Structure (2015)

A bifunctional role for the UHRF1 UBL domain in the control of hemi-methylated DNA-dependent histone ubiquitylation

Por DaRosa, Paul A., Harrison, Joseph S., Zelter, Alex, Davis, Trisha N., Brzovic, Peter, Kuhlman, Brian, Klevit, Rachel E
Publicado no Mol Cell (2018)

Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases

Por Pruneda, Jonathan N., Littlefield, Peter J., Soss, Sarah E., Nordquist, Kyle A., Chazin, Walter J., Brzovic, Peter S., Klevit, Rachel E.
Publicado em 2012

Tuning BRCA1 and BARD1 activity to investigate RING ubiquitin ligase mechanisms

Por Stewart, Mikaela D., Duncan, Emily D., Coronado, Ernesto, DaRosa, Paul A., Pruneda, Jonathan N., Brzovic, Peter S., Klevit, Rachel E.
Publicado no Protein Sci (2017)

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5: INSIGHTS INTO NUCLEOTIDE SPECIFICITY, DIMERIZATION, AND cGMP-DEPENDENT CONFORMATIONAL CHANGE

Por Heikaus, Clemens C., Stout, Joseph R., Sekharan, Monica R., Eakin, Catherine M., Rajagopal, Ponni, Brzovic, Peter S., Beavo, Joseph A., Klevit, Rachel E.
Publicado em 2008

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

Por Puvar, Kedar, Iyer, Shalini, Fu, Jiaqi, Kenny, Sebastian, Negrón Terón, Kristos I., Luo, Zhao-Qing, Brzovic, Peter S., Klevit, Rachel E., Das, Chittaranjan
Publicado no Nat Commun (2020)

The acidic transcription activator Gcn4 binds the Mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex

Por Brzovic, Peter S., Heikaus, Clemens C., Kisselev, Leonid, Vernon, Robert, Herbig, Eric, Pacheco, Derek, Warfield, Linda, Littlefield, Peter, Baker, David, Klevit, Rachel E., Hahn, Steven
Publicado em 2011

Structural and functional characterization of the monomeric U-box domain from E4B

Por Nordquist, Kyle A., Dimitrova, Yoana N., Brzovic, Peter S., Ridenour, Whitney B., Munro, Kim A., Soss, Sarah E., Caprioli, Richard M., Klevit, Rachel E., Chazin, Walter J.
Publicado em 2010