Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases

Despite the widespread importance of RING/U-box E3 ubiquitin ligases in ubiquitin (Ub) signaling, the mechanism by which this class of enzymes facilitates Ub transfer remains enigmatic. Here we present a structural model for a RING/U-box E3:E2~Ub complex poised for Ub transfer. The model and additio...

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Hlavní autoři: Pruneda, Jonathan N., Littlefield, Peter J., Soss, Sarah E., Nordquist, Kyle A., Chazin, Walter J., Brzovic, Peter S., Klevit, Rachel E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3462262/
https://ncbi.nlm.nih.gov/pubmed/22885007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.07.001
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