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Structure of an E3:E2~Ub complex reveals an allosteric mechanism shared among RING/U-box ligases
Despite the widespread importance of RING/U-box E3 ubiquitin ligases in ubiquitin (Ub) signaling, the mechanism by which this class of enzymes facilitates Ub transfer remains enigmatic. Here we present a structural model for a RING/U-box E3:E2~Ub complex poised for Ub transfer. The model and additio...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3462262/ https://ncbi.nlm.nih.gov/pubmed/22885007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.07.001 |
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