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Activation of UbcH5c~Ub is the result of a shift in inter-domain motions of the conjugate when bound to the U-box E3 ligase E4B
Post-translational modification of proteins with ubiquitin is mediated by dynamic multi-enzyme machinery (E1, E2, E3). E3 ubiquitin ligases play a key role acting as both scaffolds to bring reactants together and activators to catalyze ubiquitin (Ub) transfer from E2~Ub conjugates to substrates. Our...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3666176/ https://ncbi.nlm.nih.gov/pubmed/23550736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3015949 |
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