The acidic transcription activator Gcn4 binds the Mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex

The structural basis for binding of the acidic transcription activator Gcn4 and one activator-binding domain of the Mediator subunit Gal11/Med15 was examined by NMR. Gal11 activator-binding domain 1 has a four-helix fold with a small shallow hydrophobic cleft at its center. In the bound complex, eig...

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Autori principali: Brzovic, Peter S., Heikaus, Clemens C., Kisselev, Leonid, Vernon, Robert, Herbig, Eric, Pacheco, Derek, Warfield, Linda, Littlefield, Peter, Baker, David, Klevit, Rachel E., Hahn, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246216/
https://ncbi.nlm.nih.gov/pubmed/22195967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.11.008
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