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A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

Although many transcription activators contact the same set of coactivator complexes, the mechanism and specificity of these interactions have been unclear. For example, do intrinsically disordered transcription activation domains (ADs) use sequence-specific motifs, or do ADs of seemingly different...

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Autori principali: Warfield, Linda, Tuttle, Lisa M., Pacheco, Derek, Klevit, Rachel E., Hahn, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151740/
https://ncbi.nlm.nih.gov/pubmed/25122681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1412088111
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