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Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

Transcription activation domains (ADs) are inherently disordered proteins that often target multiple coactivator complexes, but the specificity of these interactions is not understood. Efficient transcription activation by yeast Gcn4 requires its tandem ADs and four activator-binding domains (ABDs)...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Tuttle, Lisa M., Pacheco, Derek, Warfield, Linda, Luo, Jie, Ranish, Jeff, Hahn, Steven, Klevit, Rachel E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908246/
https://ncbi.nlm.nih.gov/pubmed/29562181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.097
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