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The ubiquitin ligase SspH1 from Salmonella uses a modular and dynamic E3 domain to catalyze substrate ubiquitylation

SspH/IpaH bacterial effector E3 ubiquitin (Ub) ligases, unrelated in sequence or structure to eukaryotic E3s, are utilized by a wide variety of Gram-negative bacteria during pathogenesis. These E3s function in a eukaryotic environment, utilize host cell E2 ubiquitin-conjugating enzymes of the Ube2D...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Cook, Matt, Delbecq, Scott P., Schweppe, Thomas P., Guttman, Miklos, Klevit, Rachel E., Brzovic, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6341402/
https://ncbi.nlm.nih.gov/pubmed/30459234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004247
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