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Ubiquitylation of active Rac1 by the E3 Ubiquitin-Ligase HACE1
Rho GTPases undergo ubiquitylation and degradation via the ubiquitin-proteasome pathway. We now report in the November issue of Developmental Cell that the E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of GTP-bound Rac1. Depletion of HACE1 leads to an increase of Rac1 activity. We have prop...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3408975/ https://ncbi.nlm.nih.gov/pubmed/22790197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.19221 |
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