Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

The E3 ubiquitin ligase HACE1 is a potent tumor suppressor that controls cell proliferation and ubiquitylates the small GTPase Rac1 to target it to proteasomal degradation. Whether and how the activity of HACE1 is regulated by the N-terminal ankyrin (ANK) and the middle (MID) domains is ill defined....

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Publicado no:Sci Rep
Main Authors: Andrio, Emilie, Lotte, Romain, Hamaoui, Daniel, Cherfils, Jacqueline, Doye, Anne, Daugaard, Mads, Sorensen, Poul H., Bost, Frédéric, Ruimy, Raymond, Mettouchi, Amel, Lemichez, Emmanuel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357957/
https://ncbi.nlm.nih.gov/pubmed/28317937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44779
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