HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner

Uncovering the mechanisms that underpin how tumor cells adapt to microenvironmental stress is essential to better understand cancer progression. The HACE1 (HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase) gene is a tumor suppressor that inhibits the growth, invasive capacity, a...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Turgu, Busra, Zhang, Fan, El-Naggar, Amal, Negri, Gian Luca, Kogler, Melanie, Tortola, Luigi, Johnson, Fraser, Ng, Tony, Li, Amy, Yapp, Donald, Lockwood, William, Martinez, Daniel, Maris, John M., Daugaard, Mads, Penninger, Josef M., Hughes, Christopher S., Sorensen, Poul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979542/
https://ncbi.nlm.nih.gov/pubmed/33603169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-021-01680-1
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